Combined transcranial alternating current stimulation and perceptual learning for vision improvement in a single-case study of cone dystrophy

Cone dystrophy is a rare genetic disorder characterized by the progressive degeneration of cone photoreceptors, resulting in significant visual impairment. This multiple baseline single-case study explored the effects of combining peri-orbital transcranial alternating current stimulation (tACS) with perceptual learning to enhance visual function in a patient with cone dystrophy.

We assessed visual acuity, Vernier acuity, and contrast sensitivity, and conducted a Tau-U analysis to evaluate the results. While the Study revealed promising improvements in several visual functions, particularly in the early stages of testing, the specific impact of tACS was not evident.

Our findings suggest that perceptual learning may have the potential to improve visual perception in individuals with cone dystrophy. However, further Research with larger and more diverse populations is necessary to determine the true efficacy of peri-orbital tACS and to better understand the mechanisms underlying the observed improvements.